Recurrent implantation failure and recurrent miscarriage
What Are Recurrent Implantation Failure and Recurrent Pregnancy Loss?
Recurrent implantation failure refers to a condition in which transferred embryos fail to successfully implant in the endometrium three or more times.
Recurrent implantation failure and recurrent pregnancy loss are not conditions that should lead to giving up. With accurate diagnosis of the various underlying causes and personalized treatment strategies, they can often be overcome. It is important to communicate actively with experienced medical professionals without losing hope and to find the treatment approach that is best suited to your individual needs.
Causes
- Embryonic factors (chromosomal abnormalities)
- Structural factors of the uterus
- Immunological factors
- Endocrinological factors
- Genetic factors
- Lifestyle factors (smoking, alcohol consumption, obesity, and stress)
- Blood coagulation disorders
Treatment Methods
Based on the diagnostic results, a personalized treatment plan is developed according to the underlying cause for each individual. Treatment methods vary depending on the cause, and the following approaches may be considered.
Embryonic Factors
Embryo chromosomal testing followed by transfer of chromosomally normal embryos; assisted reproductive techniques to improve egg and sperm quality
Uterine Factors
Removal of uterine fibroids/polyps, removal of intrauterine adhesions, correction of uterine anomalies, endometrial scratching, and PRP treatment
Immunological Factors
Immunosuppressants, steroids, low-dose aspirin, heparin, and intravenous immunoglobulin (IVIG) injections
Endocrinological Factors
Thyroid function-regulating medications, progesterone supplementation, ovulation-inducing medications, and management of Polycystic Ovary Syndrome (PCOS)
Lifestyle Factors
Education and counseling on maintaining a healthy lifestyle
Genetic Factors
Assess the condition of the embryos before transfer through genetic counseling, preimplantation genetic testing (PGT), embryo screening, and other methods
Blood Coagulation Disorders
Help promote implantation and maintain pregnancy through anticoagulant therapy
Other Factors
Improve implantation rates by modifying the existing embryo transfer method and timing, adjusting the dosage and administration method of various luteal-phase support medications, and utilizing embryo glue, assisted hatching, and blastocyst-stage embryo transfer
Intrauterine Platelet-Rich Plasma Injection (Platelet-Rich Plasma Injection)
The reason intrauterine platelet-rich plasma injection is gaining attention is its potential to overcome the limitations of conventional assisted reproductive technologies and fundamentally improve endometrial function. In addition to playing a role in blood coagulation, platelets contain various growth factors that are important for promoting the regeneration of damaged tissue and inducing angiogenesis. PRP treatment, which concentrates these abundant platelet-derived growth factors and directly injects them into the uterus, offers a new potential solution for various causes of infertility, including thin endometrium, recurrent implantation failure, and chronic endometritis.